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latest articles
Three-dimensional culture model of urothelial carcinoma cell lines: current advances, challenges and future perspective
by Mansor
S.,
Syafiq
T.,
Yahaya
B.
Summary: Despite the high number of cases reported, studies describing the pathogenesis of urothelial carcinoma (UC) remain limited. This is due to insufficient in vivo models that can accurately recapitulate the pathogenesis of UC recurrence and elucidate the involvement of the tumour microenvironment (TME) during carcinogenesis. Models of cancer pathomechanism in monolayer culture provide inaccurate resemblance due to biophysical and chemical changes. In simplified 2D culture conditions, factors such as tissue architecture, cell-to-cell and cell-to-matrix interaction, and mechanical and biochemical networks, all of which are involved in drug response, are lost. Three-dimensional (3D) culture of clinical biopsy is considered an ideal model to understand UC pathogenesis, the role of the microenvironment, and mechanical adaptations due to improved translational capacity. However, limited biopsies and challenges in primary cell culturing have shifted researchers towards developing cell line-based 3D culture in the pursuit of pathomechanism exploration. A comprehensive literature evaluation was carried out by searching the PubMed, Scopus, and Web of Science databases from January 2000 to May 2022. The initial search yielded 525 articles, and 195 studies were selected based on the inclusion and exclusion criteria. This review highlights recent challenges, future strategies, and the clinical implications of developing high-throughput, cell line-based 3D models for personalized UC treatment, a critical gap in the current literature.
Moringa seeds mitigate oxidative stress and promote antioxidant activity in aging male rats
by Hamed
N.,
Hammad
H.,
Abdou
M.
Summary: The aim of this study was to examine the antioxidant effects of one of the natural plant sources against oxidative stress caused by aging. Moringa oleifera seeds (MOS), the less utilized part, were chosen to investigate their role against oxidative stress in aging male albino rats.
Up-regulation of miR-485-3p in Iranian patients with relapsing-remitting multiple sclerosis by targeting HLADRB1
by Firouzabad
M.,
Seifati
S.
Summary: Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation in the central nervous system (CNS). MicroRNAs (miRNAs) are tiny molecules that act as regulators within cells, influencing various processes linked to diseases like MS. Understanding the specific role of miRNAs in MS is crucial for developing new treatment strategies. This study focused on an Iranian population with relapsing-remitting MS. The researchers aimed to examine the levels of a particular miRNA, miR-485-3p, and its target gene, HLADRB1, over a minimum two-month period. By investigating these molecules, the study sought to shed light on the potential involvement of miR-485-3p in the pathogenesis of MS.
Relationship between Covid-19 pneumonia intensity with lymphopenia and CRP levels
by Panahi
M.,
Bolvardi
E.,
Disfani
H.,
Layegh
P.,
Foroughian
M.,
Hoseini
S.
Summary: COVID-19 is a highly contagious and deadly disease. However, there is no accurate diagnostic test to predict its severity. The aim of this study was to determine the relationship between the lymphocyte counts and CRP levels and the severity of pulmonary involvement shown in the CT scan of the patients with pneumonia caused by COVID-19.
Methylation of HPV-16 and HPV-18 E6 promoter CpG sites in women with abnormal pap smears
by Haddadi
S.,
Pirani
M.,
Dadbinpour
A.,
Kalantar
S.
Summary: HPV-16 and HPV-18 account for around 70% of cases of invasive cervical cancer worldwide. These are highly pathogenic and high-risk genotypes. The most prevalent sexually transmitted disease is human high-risk papillomavirus (HR-HPV), which can infect anyone who engages in sexual activity at any time in their life. To evaluate the possibility that the virus causes malignant lesions in infected women with high-risk HPV types who have normal and abnormal Pap smears, the current study examined the methylation pattern of CpG islands in the oncogene promoter of high-risk HPV E6.
Severe haemolytic disease of foetus and new born due to Rhesus D alloimmunisation in highly sensitised Rhesus D negative pregnant woman
by Hassan
M.,
Noor
N.,
Ramli
M.,
Abdullah
M.,
Iberahim
S.,
Zulkafli
Z.,
Rahman
W., S.,
Bahar
R.,
Yusoff
S.
Summary: Severe hemolytic disease of the fetus and newborn (HDFN) due to red cell alloimmunization is a frequent cause of recurrent fetal loss. This condition becomes critical when standard treatments like intrauterine transfusion (IUT) or immune-modulating therapies such as therapeutic plasma exchange (TPE) and intravenous immunoglobulin (IVIG) are unavailable or not administered in a timely manner. This case report emphasizes the potential benefits of early TPE and IVIG administration.
Safety and Efficacy of Combined Oral Misoprostol and Foley Catheter Treatment in Comparison with Oral Misoprostol Alone for Labor Induction: A Randomized Clinical Trial study
by Beyrami
S.,
Noorzadeh
M.,
Naemi
M.
Summary: In the context of a rising trend in labor induction cases, limited research has explored the efficacy of the simultaneous use of misoprostol and Foley catheter methods. This clinical trial investigates the efficacy and safety of combining these labor induction techniques compared to the use of oral misoprostol alone.
Inhibiting autophagy does not decrease drug resistance in breast cancer stem-like cells under hypoxic conditions
by Khan
B.,
Nhan
T.,
Pham
P.
Summary: Breast cancer has been one of the most frequently diagnosed cancers in women over the past decade. The presence of a breast cancer stem cell (BCSC) population within breast tumors significantly contributes to malignancy and drug resistance. Under the hypoxic conditions of breast tumors, BCSCs exhibit increased resistance to chemotherapy, complicating treatment and reducing its efficacy. Consequently, targeting BCSCs is considered a crucial strategy for breast cancer treatment. We hypothesize that the chemotherapy resistance of BCSCs is dependent on the upregulation of autophagy triggered by hypoxia. This study aims to investigate the relationship between autophagy and drug resistance of BCSCs in hypoxic conditions.
Association of stress and anxiety with Alzheimer’s: post-COVID-19 pandemic global perspective
by Khan
M.,
Ahmad
T.
Summary: Alzheimer's is a neurodegenerative disorder mainly caused by aging, diabetes, stress, depression, anxiety, hypertension, obesity, etc. This bibliometric study investigated the correlation of stress and anxiety with Alzheimer's Disease to understand recent research trends and post-COVID-19 pandemic trending topics. The Web of Science database was utilized. The analysis was performed using the R package and VOSviewer software. A total of 305 articles were characterized and analyzed. The density visualization indicates that Alzheimer's disease and oxidative stress are the most prominent terms, followed by memory, dementia, anxiety, and stress. The most productive countries were China, the United States of America, and Iran.
Mutational variants of KRAS gene versus Wild-type KRAS in the survival outcomes of Vietnamese colon cancer stage II-III
by Cuong
H.,
Loi
N.,
Ngoc
T.,
Thang
V.
Summary: Colon cancer is one of the most common cancers in Vietnam and globally. The KRAS gene (Kirsten rat sarcoma) is an oncogene showing a high mutation rate in colon cancer, affecting 30% to 40% of patients. The mutated KRAS gene, which keeps the MAPK signaling pathway permanently active, is considered a negative factor in the survival of colon cancer patients. Recently, several studies have been conducted to evaluate the specific prognoses related to distinct KRAS mutations, but the results were controversial. Mutations in different KRAS codons may impact colon cancer treatment models and prognoses. Therefore, the impacts of codon-specific KRAS mutations on survival require further clarification. This study aims to determine the associations between codon-specific KRAS mutations and survival in Vietnamese patients at stages II - III.
What is the optimal timing and solution for the intravenous infusion of thawed cryopreserved mesenchymal stem cells?
by Nguyen
T.,
Phan
K.,
Le
P.,
Pham
P.,
Vu
B.
Summary: The viability of mesenchymal stem cells (MSCs) during intravenous infusion can significantly impact treatment efficacy, particularly with thawed cryopreserved MSCs. During infusion, these thawed MSCs are suspended in saline at room temperature, which lacks nutrients and buffering capacity, leading to a gradual decline in cell viability. This study aimed to investigate the survival of thawed MSCs during intravenous infusion and propose an optimal procedure to maximize cell viability.
The proliferation of MDA-MB-231 cells is repressed by mesenchymal stem cell-mediated macrophage activation conditioned medium through the inhibition of AKT1 and YKL-39 genes
by Jumat
N.,
Yunus
M.,
Yahaya
B.,
Aziz
M.,
Rofiee
M.,
Mohamed
R.
Summary: Triple-negative breast cancer (TNBC) is characterized by a substantial presence of tumor-associated macrophages (TAMs) exhibiting an M2-like phenotype, which plays a crucial role in promoting tumor cell stemness and invasiveness. Mesenchymal stem cells (MSCs) have the ability to induce the transformation of naive macrophages (M0) into M1-like macrophages. This study delves into the interplay between MSCs and macrophages within the context of breast cancer (BC) progression using a TNBC cell line, as reprogramming of TAMs into M1-like macrophages may emerge as a promising therapeutic strategy for BC.
Predicting lymph node metastasis in gastric adenocarcinoma: Role of tumor budding and immunohistochemical expression of E-cadherin
by Nguyen
H.,
Nguyen
T.,
Tran
C.,
Dao
L.
Summary: Predicting the node status of stomach carcinoma is very useful, as it affects treatment decisions. The objective of this study was to use the immunohistochemical expression of E-cadherin and tumor budding to investigate the nodal status of gastric cancer surgical specimens as a pilot study before application to gastric cancer biopsy samples.
Effects of Orychophragmus violaceus extract OVS-2 on the structure and diversity of intestinal flora in mice with radiation intestinal injury
by Li
H.,
Du
L.,
Lu
Y.,
Cheng
X.,
Xiao
F.,
Zhang
Q.
Summary: Orchophragmus violaceus (OV) has a rich history of use in traditional Chinese medicine, spanning millennia. Its diverse physiological properties, such as anti-radiation, antibacterial, antitumor, and hepatoprotective effects, have garnered widespread recognition. This study aims to elucidate the potential of OV extracts to mitigate radiation-induced intestinal injury (RIII) and its impact on the intestinal microbiota.
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Editors' quote
Phuc Van Pham, Editor-in-Chief
Affiliation
Why publish with Biomedical Research and Therapy
Journal Information
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ISSN: 2198-4093
DOI Prefix: 10.15419
Indexed: Web of Science (ESCI, Clarivate Analytics), Scopus, Embase (Elsevier), Asean Citation Index, Google Scholar
Journal Metrics
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Speed (Median)
35 days to first decision for all manuscripts
55 days from submission to acceptance
15 days from acceptance to publicationCitation metrics
0.14 Journal Citation Indicator (JCI, 2023)
0.6 Journal Impact Factor (JIF, 2023)0.8 5-year Impact Factor (JIF, 2023)
Acceptance Rate
35.20%
Editor-in-Chief
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Phuc Van Pham, Vietnam National University Ho Chi Minh City, Viet Nam
Contact
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Editor-in-Chief: pvphuc@bmrat.org; pvphuc@vnuhcm.edu.vn
Support Team: support@bmrat.org; contact@bmrat.org
Managing Editor: managingeditor@bmrat.org
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