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latest articles
A case report: Perforation of the small intestine and sigmoid colon due to Kirschner wire migration
by Tran
D.,
Pham
T.,
Luu
D.,
Anh
H.,
Nguyen
P., D.,
Nguyen
Q.,
Hoang
H. N.
Summary: Kirschner wires (K-wires) are extensively utilized in orthopedic and trauma procedures. Several risks associated with K-wires have been documented, including a rare case of intestinal perforation caused by wire migration into the pelvis.
Artificial intelligence models and predicting implant success
by Nazari
Y.,
Lngeroodi
P.,
Maddahi
M.,
Kobravi
S.,
Amin
M.,
Bargrizaneh
A.,
Fouladi
S.
Summary: The integration of artificial intelligence (AI) into dental implantology has revolutionized the field, offering enhanced predictive capabilities that empower clinicians to optimize treatment outcomes. By leveraging AI, dental professionals can analyze vast amounts of patient data with unprecedented accuracy and efficiency. This advancement not only improves patient outcomes but also reduces healthcare costs by minimizing complications and streamlining treatment planning. Furthermore, AI paves the way for more personalized and successful patient care. Despite these promising developments, significant research gaps remain. These include understanding how to optimally integrate AI with diverse clinical datasets and addressing variability in patient responses. The integration of AI into dental implantology enhances not only the precision and efficiency of treatment planning and execution but also enables a more tailored approach to patient care. This review explores the potential of machine learning approaches in predicting the success of dental implant procedures. Additionally, it highlights the benefits of combining AI-generated predictions with patient-specific factors, such as bone quality, implant location, and overall health status. By adopting this holistic approach, clinicians can achieve a more accurate and personalized assessment of implant success probability, ultimately improving treatment planning and long-term outcomes.
Unravelling the role of stem cell-derived exosomes in oral cancer treatment: A review
by Memon
M.,
Shahidan
W., N., S.,
Mahmood
R.,
Kannan
T., P.,
Mustaffa
K., M., F.,
Mohamad
S.,
Mizusawa
N.
Summary: Oral cancer is the sixteenth most prevalent cancer globally, with Asian countries accounting for two-thirds of cases. Despite advancements in surgery, chemotherapy, and radiotherapy, late diagnosis, the absence of specific biomarkers, and the high cost of treatment result in poor outcomes. Tumor recurrence remains a significant challenge, highlighting the need for innovative therapeutic strategies. One promising avenue is the study of exosomes, which carry biomolecules like proteins, lipids, DNA, RNA, and microRNA, playing a key role in intercellular communication and the tumor microenvironment. Stem-cell-derived exosomes could revolutionize cancer therapy by targeting tumors and modulating immune responses. MicroRNAs within these exosomes are crucial in cancer progression, metastasis, and aggressiveness, contributing to high recurrence rates in oral cancer.
Mitochondria in the reproduction system and mitotherapy in assisted reproductive technology: the importance of mitochondria selection
by Phan
O., T., H.,
Trinh
T., T., C.,
Nguyen
V. T. T.
Summary: Mitochondria are central to energy production and are crucial for the proper operation of the reproductive system. Mitochondrial function and capacity determine whether germ cells are fertilizable, and embryos can safely reach developmental expectations. Impaired mitochondrial biogenesis and defects in mitochondrial DNA result in low birth rates, infertility, and, more seriously, unhealthy offspring with inherited and irreversible metabolic diseases. In recent years, mitochondrial transfer and transplantation have contributed greatly to the field of assisted reproductive technology, especially with advances in biotechnology. Much effort has been invested in refining mitotherapy techniques, aiming at improving the safety, efficacy, and accessibility of the treatment, while reducing costs, labor, and ethical issues. Recent research has shown numerous changes in the approaches with innovative ideas and new materials. This review highlights the role of mitochondria in the reproductive system and the current efforts to improve the outcomes in ART cases with mitochondrial issues. We also summarize different types of mitochondrial transplantation techniques and emphasize the importance of mitochondria selection for reproductive purposes.
Non-achievement of low-density lipoprotein cholesterol goal and related factors among elderly outpatients in Viet Nam: A cross-sectional study
by Ho
D., S.,
Le
T., V.,
Dinh
H., C.,
Nguyen
T.,
Ngo
D., K.,
Nguyen
C. D.
Summary: Dyslipidemia, particularly elevated serum low-density lipoprotein cholesterol (LDL-C), plays a crucial role in the development and progression of atherosclerosis. This study aimed to determine the rate of LDL-C non-achievement according to the European Society of Cardiology/European Atherosclerosis Society 2019 (ESC/EAS 2019) guidelines and related factors in the elderly.
Nocturnal high blood pressure and left ventricular hypertrophy in patients with chronic kidney disease
by Do
T., M.,
Nguyen
S., V.,
Vo
D., T.,
Tran
H., L.,
Nguyen
S., T.,
Pham
D. T. M.
Summary: Patients diagnosed with chronic kidney disease (CKD) have a heightened risk of developing masked uncontrolled hypertension (MUCH), leading to hypertension-induced organ damage. This study aimed to estimate the prevalence and characteristics of MUCH and to investigate risk factors of left ventricular hypertrophy (LVH) in those with CKD.
Unveiling the anticancer effect of citral through inhibition of stemness in estrogen-positive breast cancer
by Rusli
M., E., F., B.,
Rosli
R., B.,
Allegrucci
C.,
Saad
N.
Summary: Breast cancer remains a significant challenge due to disease recurrence and metastasis, often attributed to the persistence of treatment-resistant breast cancer stem cells (BCSCs). Citral, a compound derived from lemongrass essential oil, has demonstrated cytotoxic effects on various cancers, including breast cancer. This study investigates the anticancer mechanisms of Citral in BCSC-enriched 3D cultured spheroids and evaluates its therapeutic potential for estrogen receptor-positive breast cancer.
Advanced esophageal squamous cell carcinoma with rare metastases to the thyroid gland and supraclavicular lymph node: a case report
by Nguyen
D.,
Dao
H.,
Dinh
T.,
Vu
D.,
Dang
C.
Summary: Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with a propensity for metastatic spread. Metastasis to the thyroid gland is a rare occurrence, with few reported cases in the literature. This report presents a rare case of advanced ESCC with metastases to the thyroid and supraclavicular lymph node, highlighting the importance of considering metastatic disease in patients with unusual thyroid lesions and a history of ESCC.
Evaluating the efficacy of preoperative radiotherapy in breast cancer patients non-responsive to neoadjuvant chemotherapy: A clinical trial
by Muslumanoglu
M.,
Ozkurt
E.,
Emiroglu
S.,
Ibis
K.,
Abuaisha
A.,
Tukenmez
M.,
Cabioglu
N.,
Igci
A.,
Ozmen
V.,
Kucucuk
N.
Summary: Neoadjuvant chemotherapy (NACT) is a prevalent treatment strategy for patients with locally advanced breast cancer (LABC). Achieving a pathologic complete response (pCR) is a critical determinant of favorable outcomes. To enhance response rates, some clinicians have incorporated radiotherapy (RT) prior to surgery.
Application of artificial intelligence in the diagnosis of haematological disorders
by Almbaidin
H.,
Abeden
Z.,
Alhawamdeh
M.,
Nazman
H., N., M.,
Hamdani
H., Y.,
Yusoff
N., M.,
Isa
A.
Summary: There is a broad spectrum of hematological diseases, and their origins can be attributed to a variety of factors, including genetic abnormalities such as leukemia, sickle cell anemia (SCA), and thalassemia, as well as conditions associated with the lack of certain blood components, such as iron deficiency anemia (IDA). Testing and analyzing for hematological disorders is intensive in terms of time, effort, and labor. Additionally, there is a higher chance of human error and variance during the manual examination and analysis of the test samples, depending on the expertise, skills, and experience of the examiner. Recent developments in artificial intelligence (AI), such as Machine Learning (ML) and Deep Learning (DL) algorithms—such as Random Forest (RF), Decision Tree (DT), and Support Vector Machine (SVM)—have demonstrated the considerable contribution they could make to more rapid and accurate disease diagnosis, detection, and classification. An increasing number of hematological diseases are being diagnosed using AI techniques, which combine tabular and image data to eliminate human error, generate more precise results, and decrease the time required for diagnosis. This review discusses several widely utilized AI disease evaluation algorithms and their applicability to hematological disorders. Additionally, we highlight key challenges such as the lack of accessible clinical data, which inhibits the implementation of AI in the field of medicine.
Exosomes derived from mesenchymal stem cells: A novel agent for skin aging treatment
by Nguyen
S.
Summary: Skin aging, influenced by both intrinsic and extrinsic factors, leads to structural and functional deterioration characterized by wrinkles, reduced elasticity, and impaired wound healing. Mesenchymal stem cell-derived exosomes (MSC-exos) have emerged as a promising therapeutic option, offering multifaceted benefits for skin rejuvenation. These nano-sized extracellular vesicles exhibit exceptional bioavailability, biocompatibility, and immunomodulatory properties, addressing challenges associated with conventional treatments. MSC-exos enhance collagen synthesis, modulate inflammation, and promote angiogenesis through molecular pathways such as PI3K/Akt and Notch signaling. Furthermore, their ability to deliver bioactive molecules precisely to target cells underscores their therapeutic potential in skin repair and anti-aging applications. However, challenges remain regarding large-scale production, targeting efficiency, and regulatory frameworks, warranting further research to translate these innovative therapies into clinical practice.
Therapeutic potentials of mesenchymal stem cells for cognitive impairment in stroke: Evidence from preclinical studies
by Roza
P.,
Maryanti
Y.,
.
U.,
Saputra
N., P., K.,
Arfianti
A.
Summary: Stroke is a debilitating neurological disorder that frequently results in cognitive impairments, significantly affecting the quality of life of post-stroke patients. Current therapeutic options for poststroke cognitive impairment (PSCI) are limited. Mesenchymal stem cells (MSCs) have emerged as a promising strategy for enhancing neurological recovery, including cognitive function. This review evaluates the application of MSCs in improving cognitive function in stroke patients, focusing on data from preclinical studies. Approximately 75% of strokes occur in the elderly population, and animal models have been developed to study the effects of MSCs on ischemic stroke in aged rats, as well as in the presence of comorbidities such as hypertension and diabetes. The potential of MSCs to enhance cognitive function following a stroke is believed to involve multiple mechanisms, including the secretion of trophic factors, immunomodulation, differentiation into neural cell types, promotion of angiogenesis, and replacement of damaged cells. However, several challenges remain to be addressed, including a lack of clear understanding of the biological processes contributing to MSC efficacy, standardization of MSC preparation, and determination of optimal treatment protocols. Further studies on the specific mechanisms of action and clinical application of MSCs are required to confirm their therapeutic efficacy for stroke patients. The development of innovative and targeted therapies for PSCI will ultimately improve the quality of life for stroke survivors.
Primary evaluation the effects of Boesenbergia pandurata ethanol extract on etoposide-induced senescence in fibroblasts
by Vo
P.,
Do
N.,
Nguyen
S.
Summary: Cellular senescence is an extensively researched issue aimed at influencing the aging process. A novel research direction involves studying the potential of plant extracts on this process. Boesenbergia pandurata (Roxb.) Schltr, also known as Boesenbergia rotunda (L.) Mansf, is a herb with significant potential for research into its effects on aging. Furthermore, it is crucial to study cellular senescence models to accurately assess the impact of various agents on the aging process.
The relationship between MBL2 levels and NLRP3 in acute ischemic stroke: Insights from a proteomics study
by Zhu
B.,
Li
X.,
Tian
Y.,
Yang
H.,
Wu
M.,
Wang
S.,
Wang
B.,
Zhao
Z.
Summary: Inflammation plays a pivotal role in the pathogenesis of stroke. However, the proteins that initiate inflammatory responses remain unclear. In this study, we utilize proteomics to identify the core protein in acute ischemic stroke (AIS) patients and verify the relationship of the protein with NOD-like receptor protein 3 (NLRP3).
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Editors' quote
Phuc Van Pham, Editor-in-Chief
Affiliation
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Journal Information
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ISSN: 2198-4093
DOI Prefix: 10.15419
Indexed: Web of Science (ESCI, Clarivate Analytics), Scopus, Embase (Elsevier), Asean Citation Index, Google Scholar
Journal Metrics
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Speed (Median)
35 days to first decision for all manuscripts
55 days from submission to acceptance
15 days from acceptance to publicationCitation metrics
0.14 Journal Citation Indicator (JCI, 2023)
0.6 Journal Impact Factor (JIF, 2023)0.8 5-year Impact Factor (JIF, 2023)
Acceptance Rate
35.20%
Editor-in-Chief
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Phuc Van Pham, Vietnam National University Ho Chi Minh City, Viet Nam
Contact
-
Editor-in-Chief: pvphuc@bmrat.org; pvphuc@vnuhcm.edu.vn
Support Team: support@bmrat.org; contact@bmrat.org
Managing Editor: managingeditor@bmrat.org
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