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latest articles
Primary evaluation the effects of Boesenbergia pandurata ethanol extract on etoposide-induced senescence in fibroblasts
by Vo
P.,
Do
N.,
Nguyen
S.
Summary: Cellular senescence is an extensively researched issue aimed at influencing the aging process. A novel research direction involves studying the potential of plant extracts on this process. Boesenbergia pandurata (Roxb.) Schltr, also known as Boesenbergia rotunda (L.) Mansf, is a herb with significant potential for research into its effects on aging. Furthermore, it is crucial to study cellular senescence models to accurately assess the impact of various agents on the aging process.
The relationship between MBL2 levels and NLRP3 in acute ischemic stroke: Insights from a proteomics study
by Zhu
B.,
Li
X.,
Tian
Y.,
Yang
H.,
Wu
M.,
Wang
S.,
Wang
B.,
Zhao
Z.
Summary: Inflammation plays a pivotal role in the pathogenesis of stroke. However, the proteins that initiate inflammatory responses remain unclear. In this study, we utilize proteomics to identify the core protein in acute ischemic stroke (AIS) patients and verify the relationship of the protein with NOD-like receptor protein 3 (NLRP3).
Hemocyanin is a major allergen in local mud crab Scylla paramamosain in Viet Nam
by Le
K.,-M.,
Trinh
H., K., T.,
Van
T., N., V.,
Pham
D., L.,
Nguyen
H., T.,
Tran
T.,-T.,
Thi
M., N., T.,
Pham
B., Y.,
Pham
D. M.
Summary: Shellfish allergy is prevalent in coastal countries across Asia. Despite crab being a popular dish, there is limited knowledge about the features of crab allergy in Viet Nam. This study aims to identify the IgE-binding allergens in the local crab species, Scylla paramamosain (S. paramamosain).
Platelet-rich plasma therapy for meibomian gland dysfunction and dry eye: A mini review
by Nguyen
S.,
Pham
P.
Summary: A common eye condition known as dry eye syndrome is characterized by insufficient tear production or rapid tear evaporation, causing dryness, irritation, and pain. A common etiological cause for dry eye disease (DED) that affects both the composition and production of tears is meibomian gland dysfunction (MGD). Meibum, an oily substance produced by the meibomian glands, is essential for preventing tear evaporation. The temporary alleviation offered by standard dry eye therapies has prompted researchers to investigate new therapeutic modalities. Platelet-rich plasma (PRP) therapy has been identified as a viable approach for stimulating meibomian gland activity and improving tear production in dry eye patients. Highly concentrated platelets and growth factors found in PRP are essential for promoting tissue regeneration and accelerating the healing process. By the application or injection of PRP in the affected region, the growth factors could stimulate the production and release of meibum, thereby improving the functionality of the meibomian glands and reinstating the stability of the tear film. The objective of this review article is to conduct a comprehensive analysis of clinical evidence supporting the utilization of PRP therapy in managing MGD and dry eye syndrome. Several studies have demonstrated the efficacy of PRP therapy in enhancing meibomian gland function, mitigating ocular surface inflammation, and alleviating symptoms associated with dry eye. Based on the research outcomes, it has been determined that PRP therapy exhibits potential efficacy as a novel intervention for treating dry eye syndrome. This therapeutic approach demonstrates the ability to enhance the health of the ocular surface and target the fundamental etiological factors associated with this condition. Additional research and investigation are required to ascertain the optimal protocols and long-term efficacy of PRP therapy in treating dry eye and MGD. In conclusion, PRP therapy represents a promising and effective treatment option for patients suffering from dry eye syndrome and MGD, offering significant improvements in ocular surface health and patient quality of life.
miRNAs in Melanoma: Diagnostic, prognostic, and therapeutic strategies
by Evyapan
G.,
Ozdem
B.,
Aksoy
G.
Summary: Melanoma is a highly aggressive and deadly form of skin cancer, with its incidence and mortality rates increasing significantly worldwide. Recent research suggests that miRNA-based therapies could help improve outcomes for melanoma patients by controlling gene expression at the posttranscriptional level, which affects how the tumor grows and spreads. This review aims to examine the role of microRNAs (miRNAs) in melanoma progression, highlighting their potential as therapeutic targets and exploring how they may be utilized in diagnostic and prognostic processes.
Results response of neoadjuvant chemotherapy for stage III breast carcinoma at Viet Nam National Cancer Hospital
by Thien
N.,
Quang
L.,
Trung
N.
Summary: To characterize the clinical and paraclinical features of stage III breast carcinoma (BC) and evaluate the response to neoadjuvant chemotherapy (NAC).
Platelet rich plasma driven changes in hepatic glycogen metabolism and hepato-histological assessment in diabetic mice
by Arif
A.,
Shakir
M.,
Shahzad
A.,
Kawish
N.,
Sheikh
N.,
Abbasi
M.,
Khawar
M.
Summary: Platelet-rich plasma (PRP) emerges as a promising therapy, exhibiting noticeable anti-diabetic potential. Nevertheless, the precise underlying mechanism remains enigmatic. In the current investigation, we aimed to scrutinize the potential therapeutic ramifications of PRP in alloxan-induced diabetic mice, with a particular focus on its modulation of glycogen metabolism and glucose transport.
Association of P73, BMP15, and GDF9 gene polymorphisms with diminished ovarian reserve
by Ghasemifar
S.,
Kalantar
S., M.,
Babakhanzadeh
E.,
Mirabutalebi
S., H.,
Khodadadian
A.,
Nazari
M.,
Ghasemi
N.
Summary: Diminished ovarian reserve (DOR) is a condition in which the quantity or quality of oocytes results in impaired fertility. The prevalence of DOR in infertile women is estimated to be around 10%. Our aim was to investigate the polymorphisms rs3810682, rs10491279, and rs4648551 in association with the genes BMP15, GDF9, and p73 in patients with DOR and control samples.
A laboratory study on N-acetyl cysteine in SSP+ modulating oxidative stress and delaying the progression of storage lesion in platelets
by Rajanand
M.,
Ananthakrishna
A.,
Rajashekaraiah
V.
Summary: Oxidative stress (OS) contributes to platelet storage lesion (PSL) and can be attenuated by using antioxidant additives in the storage solution. N-acetyl cysteine (NAC), a thiolcontaining antioxidant, scavenges reactive oxygen species (ROS) directly, upregulates antioxidant defenses, and has anti-apoptotic properties. This study explores the effect of the antioxidant additive NAC on platelets during storage.
The role of inflammation and oxidative stress markers in the occurrence and severity of coronary artery disease in young patients with ST-segment elevation myocardial infarction
by Gaber
M.,
Omar
O.,
Meki
A.,-R.,
Nassar
A.,
Hassan
A.,
Mahmoud
M.
Summary: Atherosclerosis is modulated by inflammation and oxidative stress, which play pivotal roles in the pathogenesis of coronary artery disease (CAD), especially in young patients without traditional risk factors for atherosclerosis. In this study, we aimed to study the role of some inflammatory and oxidative stress markers in triggering ST segment elevation myocardial infarction in Egyptian young patients and the potential correlation to the severity of coronary artery lesions in the Egyptian population.
Three-dimensional culture model of urothelial carcinoma cell lines: current advances, challenges and future perspective
by Mansor
S.,
Syafiq
T.,
Yahaya
B.
Summary: Despite the high number of cases reported, studies describing the pathogenesis of urothelial carcinoma (UC) remain limited. This is due to insufficient in vivo models that can accurately recapitulate the pathogenesis of UC recurrence and elucidate the involvement of the tumour microenvironment (TME) during carcinogenesis. Models of cancer pathomechanism in monolayer culture provide inaccurate resemblance due to biophysical and chemical changes. In simplified 2D culture conditions, factors such as tissue architecture, cell-to-cell and cell-to-matrix interaction, and mechanical and biochemical networks, all of which are involved in drug response, are lost. Three-dimensional (3D) culture of clinical biopsy is considered an ideal model to understand UC pathogenesis, the role of the microenvironment, and mechanical adaptations due to improved translational capacity. However, limited biopsies and challenges in primary cell culturing have shifted researchers towards developing cell line-based 3D culture in the pursuit of pathomechanism exploration. A comprehensive literature evaluation was carried out by searching the PubMed, Scopus, and Web of Science databases from January 2000 to May 2022. The initial search yielded 525 articles, and 195 studies were selected based on the inclusion and exclusion criteria. This review highlights recent challenges, future strategies, and the clinical implications of developing high-throughput, cell line-based 3D models for personalized UC treatment, a critical gap in the current literature.
Moringa seeds mitigate oxidative stress and promote antioxidant activity in aging male rats
by Hamed
N.,
Hammad
H.,
Abdou
M.
Summary: The aim of this study was to examine the antioxidant effects of one of the natural plant sources against oxidative stress caused by aging. Moringa oleifera seeds (MOS), the less utilized part, were chosen to investigate their role against oxidative stress in aging male albino rats.
Up-regulation of miR-485-3p in Iranian patients with relapsing-remitting multiple sclerosis by targeting HLADRB1
by Firouzabad
M.,
Seifati
S.
Summary: Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation in the central nervous system (CNS). MicroRNAs (miRNAs) are tiny molecules that act as regulators within cells, influencing various processes linked to diseases like MS. Understanding the specific role of miRNAs in MS is crucial for developing new treatment strategies. This study focused on an Iranian population with relapsing-remitting MS. The researchers aimed to examine the levels of a particular miRNA, miR-485-3p, and its target gene, HLADRB1, over a minimum two-month period. By investigating these molecules, the study sought to shed light on the potential involvement of miR-485-3p in the pathogenesis of MS.
Relationship between Covid-19 pneumonia intensity with lymphopenia and CRP levels
by Panahi
M.,
Bolvardi
E.,
Disfani
H.,
Layegh
P.,
Foroughian
M.,
Hoseini
S.
Summary: COVID-19 is a highly contagious and deadly disease. However, there is no accurate diagnostic test to predict its severity. The aim of this study was to determine the relationship between the lymphocyte counts and CRP levels and the severity of pulmonary involvement shown in the CT scan of the patients with pneumonia caused by COVID-19.
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Editors' quote
Phuc Van Pham, Editor-in-Chief
Affiliation
Why publish with Biomedical Research and Therapy
Journal Information
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ISSN: 2198-4093
DOI Prefix: 10.15419
Indexed: Web of Science (ESCI, Clarivate Analytics), Scopus, Embase (Elsevier), Asean Citation Index, Google Scholar
Journal Metrics
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Speed (Median)
35 days to first decision for all manuscripts
55 days from submission to acceptance
15 days from acceptance to publicationCitation metrics
0.14 Journal Citation Indicator (JCI, 2023)
0.6 Journal Impact Factor (JIF, 2023)0.8 5-year Impact Factor (JIF, 2023)
Acceptance Rate
35.20%
Editor-in-Chief
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Phuc Van Pham, Vietnam National University Ho Chi Minh City, Viet Nam
Contact
-
Editor-in-Chief: pvphuc@bmrat.org; pvphuc@vnuhcm.edu.vn
Support Team: support@bmrat.org; contact@bmrat.org
Managing Editor: managingeditor@bmrat.org
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