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latest articles
Update on the use of platelet-rich plasma in the treatment of osteoarthritis: New supporting evidence
by Do-Minh
N.,
Nguyen-Trong
H.,
Vu-Bich
N.,
Pham-Van
P.
Summary: Platelet-rich plasma (PRP) therapy has gained popularity as a treatment option for osteoarthritis, despite a lack of formal endorsement by professional associations. While not universally recommended, its application in managing joint osteoarthritis and aiding ligament regeneration has received approval in several countries. Research into PRP's effectiveness in treating joint osteoarthritis presents promising outcomes, but suffers from inconsistencies across various studies. These disparities stem from differences in the methods of PRP preparation, the concentration of platelets, the frequency of injections, and the specific type of PRP utilized. This article aims to provide the most recent insights into the efficacy of PRP therapy for joint osteoarthritis, underscoring the significant impact of PRP classification, platelet dosage, and injection regimen on therapeutic outcomes. In sum, findings from this study advocate for the use of PRP in managing joint osteoarthritis, highlighting its potential benefits when applied under optimized conditions.
Gut microbiome influences incidence and outcomes of breast cancer by regulating levels and activity of steroid hormones in women
by Pathoor
N., N.,
Ganesh
P. S.
Summary: This review comprehensively examines the role of the gut microbiome in breast cancer by regulating steroid hormones, emphasizing the impact of probiotics on gut diversity and metabolic health. The discussion could be enriched with more detailed mechanistic insights and longitudinal studies.
Renal failure in a pediatric patient secondary to HCoV-NL63 infection: A case report
by Kori
A., M., M.,
Ibrahim
K.,
Jalil
N., A., C.,
Ilias
M. I.
Summary: Coronaviruses (CoVs) are members of the Nidovirales family, Coronaviridae. To date, seven human CoVs have been identified, some of which are known to circulate persistently in the human population, particularly among young infants. Among these CoV types, renal disease is a recognized complication associated with SARS-CoV-2. No cases of renal disease caused by HCoVNL63 have been reported.
Nutritional Status, Dietary Patterns, and Prealbumin as Prognostic Factors in Stroke: An Observational Study
by Koç
A.,
Ersoy
A.
Summary: Prealbumin is a protein synthesized by the choroid plexus and liver, playing integral roles in the transport of thyroxine and retinol. Its serum levels are known to decrease in response to conditions such as inflammation, protein deficiency, end-stage liver disease, and malignancy. Notably, decreased serum prealbumin levels have been negatively correlated with the severity of stroke. Given this context, understanding factors that predict functional outcomes and mortality in stroke patients is crucial, particularly the potential role of nutritional status and prealbumin levels.
Simple-Virilizing Congenital adrenal hyperplasia sustained by five mutations on the CYP21A2 gene
by Agrimonti
G.,
Spaggiari
G.,
Menabò
S.,
Vezzani
S.,
Magnani
E.,
Frasoldati
A.,
Granata
A.,
Santi
D.
Summary: Classical congenital adrenal hyperplasia is a genetic disorder characterized by defects in the steroidogenesis cascade, mainly due to 21-hydroxylase enzyme deficiency. The phenotype can vary from the most severe salt-wasting syndrome to the less severe simple-virilizing form. The genotype-phenotype correlation is complex, and it is expected that the higher the number of mutations detected, the worse the phenotype would be. Moreover, when more than one mutation occurs in the same patient, the phenotype should be the result of the most severe mutation detected.
Association study between polymorphisms within MPPED2 (rs12797813), MTR (rs61739582), ACTN2 (rs6656267) and LPO (rs7209537) genes and susceptibility to dental caries: a case-control study
by Akbarian
S.,
Daneshmehr
S.,
Nazari
Y.,
Kobravi
S.,
Fetrati
A.,
Amin
M., R.,
Biglak
B.,
Alizadeh
F.
Summary: The linkage between specific genetic variants and the susceptibility to dental caries remains a crucial area of investigation. This study aimed to examine the association of particular gene variants within MPPED2 (rs12797813), MTR (rs61739582), ACTN2 (rs6656267), and LPO (rs7209537) genes with the likelihood of developing dental caries.
Association between blood Interleukin-10 level in coronary artery disease: A systematic review, meta-analysis, and network analyses
by Moghadam
R.,
Rouzbahani
M.,
Salehi
N.,
Sadeghi
M.
Summary: Cytokines can be key factors in the pathogenesis of coronary artery disease (CAD). This systematic review and meta-analysis aimed to assess the levels of interleukin-10 (IL-10), an anti-inflammatory cytokine, in the serum/plasma of patients with CAD.
Comparative Efficacy of CNV-Sequencing and Karyotyping in Prenatal Genetic Diagnosis
by Tang
H., X.,
Pham
H., V.,
Nguyen
C., X.,
Nguyen
H., T.,
Luu
H. T.
Summary: This study aimed to compare the efficacy of Copy Number Variation sequencing (CNV-Seq) with that of traditional karyotyping in prenatal diagnostics by assessing their concordance and ability to identify aneuploidies and structural abnormalities in fetal chromosomes.
CellTravel: An injectable, defined medium for cool or ambient temperature transport and short-term storage of human mesenchymal stem cells
by Kiet
P., T.,
Trang
N., T., H.,
Phat
N., T.,
Ngoc
V., B.,
Phuc
P. V.
Summary: Mesenchymal stem cells (MSCs) are increasingly used for the treatment of various diseases. However, the treatment cost remains relatively high. One reason for this is the complexity and expense involved in the transportation and use of MSCs. Currently, most of the transport of stem cells from the production site to the hospital is carried out under cold conditions with CO2 ice or liquid nitrogen. This transportation is difficult and costly, especially from one country to another. At the site of use, the use of products is also complicated, requiring cells to be properly thawed and sometimes washed to remove cold storage medium before use. Therefore, this study aimed to investigate the transport and storage medium of MSCs at room and cool temperature (2-8 oC).
Study on gene expression of IL-17A in eutopic and ectopic tissue sample of endometriosis patients and comparison with control group
by Hoseininasab
F.,
Mehrjardi
Y., V.,
Javaheri
A.,
Tajamolian
M.,
Samadi
M.
Summary: The growth of endometrial tissue beyond the uterine cavity characterizes endometriosis, a chronic inflammatory disease. IL-17A, along with other immune mediators and a myriad of immune cells including Th17 lymphocytes and macrophages, are more prevalent in the peritoneal fluid of patients with endometriosis. IL–17A facilitates the implantation of endometrial tissue in ectopic locations by inducing growth factors and inflammatory cytokines from other immune cells. This work focuses on the levels of IL-17A gene expression in tissue samples from patient and control groups, as prior research has not extensively covered the gene expression of inflammatory mediators in tissue samples.
The value of hematological indices as predictors of septic shock in acute obstructive pyelonephritis
by Truong
M., H.,
Ngo
T., Q.,
Nguyen
Q., T.,
To
P., T.,
Tran
P., T.,
Le
H. D.
Summary: Acute Obstructive Pyelonephritis (AOP) is a severe and prevalent infection within the urinary system, prone to rapidly escalate into urosepsis and potentially result in septic shock, which poses a significant mortality risk. This study investigates the potential of certain blood parameters to serve as indicators for predicting the likelihood of developing septic shock in AOP patients.
Exploring the Effect of Phytochemical Extract (Benincasa sp.) on the Inflammatory Mediators and Regulatory Pathways of Acute Cisplatin Nephrotoxicity in Pre-clinical Mouse Model
by Pal
P.,
Banerjee
E. R.
Summary: Cisplatin-induced acute nephrotoxicity is typically manifested by a decrease in kidney function, electrolyte imbalances, and acute kidney injury (AKI). Most therapies for AKI are costly and have serious side effects. Utilizing phytotherapy for the prevention of kidney disease has the potential to reduce both treatment expenses and the occurrence of associated side effects. Benincasa cerifera (BC) offers extensive advantages owing to its anti-inflammatory, antioxidant, and anti-diabetic characteristics. This study aims to demonstrate the protective effects of BC on the inflammatory mediators and regulatory pathways in a cisplatin-induced acute kidney injury (AKI) model.
Significant Associations Between Age, Menstrual Status, and Histopathological Types of Cervical Carcinoma in Vietnamese Patients: Insights from a Retrospective and Prospective Analysis
by Pham
H., V.,
Phan
V., M.,
Bui
C., V.,
Nguyen
T., A.,
Luu
H., T.,
Tran
T., H.,
Tang
H. X.
Summary: Cervical cancer, predominantly associated with high-risk Human Papillomavirus (HPV) types 16 and 18, presents a substantial public health challenge, particularly impacting women in low and middle-income countries. This study aims to address a vital knowledge gap by examining the relationship between age, menstrual status, and histopathological types of cervical carcinoma in Vietnamese patients.
Eosinophilic Gastrointestinal Disease Presenting as Chronic Diarrhea: A Case Report
by Phan
N., T.,
Ho
P., T.,
Ma
N., P.,
Pham
T., Q.,
Quach
D. T.
Summary: Eosinophilic gastrointestinal diseases (EGIDs) constitute a spectrum of disorders distinguished by the abnormal infiltration of eosinophils into the walls of the gastrointestinal tract, a phenomenon that frequently results in delayed or overlooked diagnoses due to the nonspecific nature of symptoms and endoscopic findings. This article discusses a noteworthy case characterized by chronic diarrhea and mild abdominal discomfort. The presence of peripheral eosinophilia and the evidence obtained from biopsies raised suspicions, ultimately leading to the diagnosis of EGIDs. Despite a two-month diagnostic delay attributed to limited disease awareness, the patient responded well to medical management. The therapeutic regimen comprised methylprednisolone, ketotifen, and montelukast, complemented by dietary modifications, culminating in the full resolution of symptoms. A notable complication was the onset of severe cellulitis during steroid treatment, necessitating an expedited reduction in the steroid dosage while continuing with other medications and undertaking surgical debridement. This infection was successfully controlled, and the corticosteroid therapy was gradually tapered off and discontinued over an eight-week period. The administration of ketotifen and montelukast was maintained, with no further recurrences reported. This case exemplifies the critical need to consider EGIDs in the differential diagnosis of individuals presenting with gastrointestinal symptoms, particularly when peripheral eosinophilia is evident. Furthermore, it emphasizes the imperative of holistic patient care, inclusive of managing infectious complications that may arise during the course of treatment.
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Editors' quote
Phuc Van Pham, Editor-in-Chief
Affiliation
Why publish with Biomedical Research and Therapy
Journal Information
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ISSN: 2198-4093
DOI Prefix: 10.15419
Indexed: Web of Science (ESCI, Clarivate Analytics), Scopus, Embase (Elsevier), Asean Citation Index, Google Scholar
Journal Metrics
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Speed (Median)
35 days to first decision for all manuscripts
55 days from submission to acceptance
15 days from acceptance to publicationCitation metrics
0.14 Journal Citation Indicator (JCI, 2023)
0.6 Journal Impact Factor (JIF, 2023)0.8 5-year Impact Factor (JIF, 2023)
Acceptance Rate
35.20%
Editor-in-Chief
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Phuc Van Pham, Vietnam National University Ho Chi Minh City, Viet Nam
Contact
-
Editor-in-Chief: pvphuc@bmrat.org; pvphuc@vnuhcm.edu.vn
Support Team: support@bmrat.org; contact@bmrat.orgHandling Editor: vbngoc@bmrat.org
Managing Editor: managingeditor@bmrat.org
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