Abstract

To reduce the amount of plastic waste, world-wide programs for efficient management of utilized plastic materials, such as recycling, have been started PHAs could be completely relied on replacing the conventional plastics as they share similar thermo mechanical properties with the petrochemical based plastics. PHA exhibit high level of biocompatibility and biodegradability, hence they are used for several biomedical applications. PHA extracted from Pseudomonas plecoglossicida checked for its ability to attach cancer cells was investigated. Cancer cells showed high affinity of adherence on the PHA sheets used. Contact angle detection have proved that only cancer cells showed the adherence effect and normal cells did not exhibit such adherence property towards the PHA sheets which was further authenticated by contact angle observations. Hence, PHA sheets can be effectively used as a valid target for the contact angle detection of cancer cells.


 

Keywords: Biology Cancer cells Contact angle detection PHB Pseudomonas plecoglossicida

References

1. Alistair J. Anderson, Geoffrey W. Haywood, Edwin A. Dawes. (1990) Biosynthesis and composition of bacterial poly(hydroxyalkanoates). Int J Biol Macromol 12: 102-105
2. Anish Kumari Bhuwal, Gulab Singh, Neeraj Kumar Aggarwal, et al. (2013) Isolation and Screening of Polyhydroxyalkanoates Producing Bacteria from Pulp, Paper, and Cardboard Industry Wastes. Int J Biomat 1-10
3. Bingdi Chen, Wenjun Le1, Yilong Wang, Zhuoquan Li, Dong Wang, et al (2016) Targeting Negative Surface Charges of Cancer Cells by Multifunctional Nanoprobes. Theranostics: 1887 -1898
4. Bowtell D, Sambrook. J. (2002)DNA Microarrays, A Molecular Cloning Manual. 1st edition. New York: Cold Spring Harbor Laboratory Press
5. Brandl H, Gross RA, Lenz RW, Fuller RC. (1988) Pseudo¬monas oleovorans as a Source of Poly(β-Hydroxyal¬kanoates) for Potential Applications as Biodegradable Poly¬esters. Appl. Environ. Microbiol 54: 1977-1982

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