We presented a green, simple and economical method to synthesize carbon nanodots (C-dots) from millets using hydrothermal synthesis route. The obtained C-dots have average diameter ranging from 6 to 8 nm. Optical measurements showed the formation of hydroxyl, carbonyl/carboxyl, amino functional groups on the particle surfaces, resulting in their high hydrophilicity and bioconjugation. After treatment with C-dots, human cervical and lung cancer cells became bright and exhibited multicolor fluorescence under different excitation wavelength. The achievement demonstrated potential applications of fluorescent C-dots in the field of biomedical application, especially in diagnostic disease techniques.


1) Xiaohu G, Lily Y, John AP, Fray FM, Jonathan WS and Shuming N (2005) In vivo molecular and cellular imaging with quantum dots. Curr. Opin. Biotechnol 16:63-72 2) Murray CB, Norris DJ, Bawendi MG (1993) Synthesis and characterization of nearly monodisperse CdE (E = sulfur, selenium, tellurium) semiconductor nanocrystallites. J Am Chem Soc 115(19):8706–87153
3) He Y, Lu HT, Sai LM, Su YY, Hu M, Fan CH, Huang W, Wang LH (2008) Microwave synthesis of water-dispersed CdTe/CdS/ZnS core-shell-shell quantum dots with excellent photostability and biocompatibility. Adv Mater 20(18):3416–3421
4) Sheila NB and Gary AB (2010) Luminescent carbon nanodots: emergent nanolights. Angew. Chem. Int. Ed. 49:6726 – 6744
5) Haitao L, Zhenhui K, Yang L and Shuit TL (2012) Carbon nanodots: synthesis, properties and applications. J. Mater. Chem 22:24230–24253


Must Read