This report describes polio cases, vaccination uncertainty and challenges, and the way forward to eradicate polio from Pakistan. Numerous articles, government and non-government documents, and survey reports were studied and an online search was made to collect information on polio in Pakistan. Once again the polio vaccination program has been stopped and accused by the local community in Pakistan as a result an increase has been seen in polio cases in the last year. In 2019, a total of 117 wild poliovirus (WPV) and 18 circulating vaccine-derived poliovirus (cVDPV2) cases were reported from the country. The majority of cases were from the Khyber Pakhtunkhwa (KP) province as a result of polio vaccination uncertainty and many challenges faced by the vaccination program in the region. Pakistan reported their highest annual number of WPV cases as compared to last few years. This increase is not only an alarming threat for the country but also a key challenge for the global polio eradication movement. Increase awareness and raising immunization to over 100% in some areas especially in the remote area where every year many children missed vaccination to achieve global polio eradication goals.



Poliomyelitis is also known as polio is a highly infectious viral disease mainly infects the children under five years of age. The virus belongs to family Picornaviridae and there are three poliovirus serotypes wild poliovirus (WPV1, WPV2 and WPV3). The virus attacks the nervous system and can cause irreversible paralysis in infected individuals in a matter of hours. The virus spreads through person-to-person contact via the fecal-oral route, contaminated food and water, even though the oral-oral route transmission is possible. The incubation period usually ranges from 7 to 21 days. The initial symptoms of the disease include fever, headache, fatigue, vomiting, pain in the limbs and stiffness in the neck. However, the majority of infected individuals (90%) have very mild symptoms or no symptoms and usually go unrecognized2, 1. Polio can be prevented through vaccination. The vaccine is given multiple times, such as the first dose of vaccine is given as early as 6 weeks of age, at 4 months of age second dose is given, at 6–18 months of age the third dose is given. However, there are 2 months recommended interval between the primary series doses. In some cases, when the protection is needed to be accelerated the minimum interval between each of the first 3 doses of inactivated polio vaccine (IPV) is 4 weeks. Hence, regardless of the number of previous doses, a dose of IPV on or after age 4 years is recommended with a minimum interval of 6 months from the next-to-last to final dose1. We aimed to describe polio cases, vaccinations uncertainty and challenges, and the way forward to eradicate polio from Pakistan.


Online searches were made to collect data on polio, several government documents, survey reports and articles were studied. In addition, the World Health Organization (WHO), polio global eradication initiative and other websites were also searched.


A polio eradication movement is underway and every year a huge amount of fund has been allocated to polio immunizations in Pakistan. The global polio eradication initiative is focusing to reach to every single individual. If the polio is eradicated globally, so after smallpox it would only be the 2nd time in human history that a disease is eradicated. Since 1988, development and effective vaccines coverage resulted in 99.9% reduction of polio cases worldwide. In 1988, an estimated 350,000 wild polio cases were reported. Since, then the number has fallen significantly and in 2018, only 33 wild polio cases were reported from polio endemic countries (21 in Afghanistan, 12 in Pakistan, and 0 in Nigeria). In addition, the total number of circulating vaccine-derived poliovirus (cVDPV) were 103 in 2018, of which 69 cases reported in non-endemic countries while the remaining 34 cases were reported in Nigeria3.

Pakistan is one of the polio endemic countries due to regular intervals of polio workers insecurity and parental refusal from vaccination pushed the country far to achieve global polio eradication movement. In March 2015, an estimated (79%) children in Pakistan were vaccinated. Of the total targeted children, 33,695 (<1%) children were missed due to parent's misunderstanding and refusal. On other hand, (20%) cases were missed due to security issues in the country4.

The Federally Administered Tribal Areas (FATA) were under the control of militant groups (Taliban). These militants not only imposed ban on polio immunization but also attacked many polio workers. As a result, polio immunization has not been undertaken and many of children were left unvaccinated5. Due to this gap, in 2014 majority of the reported cases of polio were from FATA and neighboring province of Khyber Pakhtunkhwa (KP)6.

In order to beat these militants, security forces launched an operation. As a consequence, an estimated 1 million people from un-vaccinated area were migrated to different parts of the country. Among these internally displaced people (IDP), some were carried the polio virus that was transmitted in different areas of Pakistan. Pakistan has made substantial progress towards polio eradication but the game is not over yet. The statistics showed that after the significant decline in number of polio cases from 307 in 2014 to only 12 cases in 2018, the government was hoping the eradication of polio from the country but unfortunately once again the battle won by the virus and in 2019, the number of polio cases has increased with an alarming rate7.

In 2019, a total of 117 wild poliovirus type 1 (WPV1) cases have been reported in Pakistan. However, highest number of cases (n = 92) were from KP. In addition, a total of cVDPV2 cases (n = 18) were reported in the country (Table 1)8. Data showed that the disease is still endemic in rural and remote areas of KP which is an alarming threat for global polio eradication.

Table 1.

Distribution of polio cases in Pakistan during the last ten years

Province/region WPV polio cases cVDPV2
2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 Total 2019
Punjab 7 9 2 7 5 2 0 1 0 8 41 2
Sindh 27 33 4 10 30 12 8 2 1 6 152 0
KP* 98 82 47 76 247 33 10 1 8 92 694 12
Balochistan 12 73 4 0 25 7 2 3 3 11 140 o
GB 0 1 1 0 0 0 0 1 0 0 3 4
AJK 0 0 0 0 0 0 0 0 0 0 0 0
Total 144 198 58 93 307 54 20 8 12 117 1030 18

The global polio eradication movement is almost near to the finishing line but some of the anti-polio agents in Pakistan are badly affecting this campaign. Once again, the current polio vaccination campaign (22nd to 24th April 2019) has been accused by the local community and anti-polio forces in the country by imposing a ban on the polio vaccination and spreading of conspiracy theories and rumors. This happened in Peshawar, the capital city of KP. The FATA and KP have been declared as the “Hub of polio” in Pakistan as shown in Figure 1. This created a panic in the common population of KP province as well as in other parts of the country. As a result, most of the people refused to vaccinate their children9.

Figure 1 . a) Map of Asia; b) Map of Pakistan and Afghanistan. The red circle represents polio hub in Pakistan.

In every polio vaccination campaign more than 40,000 parents refuse to administer vaccine to their children in Pakistan10. During the past and the recent gunning down of polio workers has seen the polio vaccination campaign take a major setback and failure to contain. Previous studies showed that the polio vaccination coverage is far below than that required for eradication11. During the recent polio campaign, two polio workers were attacked (one get expired and other was seriously injured) in Chaman, Balochistan, Pakistan which leads to stop polio vaccination campaign12.

The polio vaccination accused might be one of the key risk factor in spreading of polio disease. In the past, India had also faced the polio vaccination refusal by certain communities. Because of the organized efforts and effective managements of government health institutions, media also played a tremendous role to achieve the targeted milestone and successfully eradicated polio13. A huge responsibility lies on the government and health authorities of polio endemic countries to ensure the safe vaccination campaign to eradicate the disease. It can be achieved by strengthen the coordination between local health authorities, community workers and non-governmental organizations.

It is predicted that if the immunization campaign get disturbed on regular intervals, the number of cases may significantly increase and the dream of polio eradication from Pakistan will not come true. One of the major obstacles in polio eradication is the worse perception of parents about polio immunization (especially in the high zone areas like KP, FATA and Karachi). It is the perception of common people that polio vaccine leads to infertility as well as this vaccine cause polio instead of treating it. To change the misconceptions of parents and local community, evidence-based approaches and strategies need to be adopted. Previous published studies showed that poor knowledge about polio immunization, religious beliefs and negative attitudes of participants are the major barriers towards polio immunization14.

Strict actions and effective policies are needed to implement on emergency basis by launching community awareness program about polio immunizations. It will be very helpful to involve all the stakes holders of the society, specially the religious leaders and scholars to whom masses follow allot. Strong surveillance network and polio workers safety can make the polio vaccination campaign effective.


Within the last few years, effective vaccine delivery, militants’ attacks and parental refusal from vaccination remained the key challenges to fight against polio in Pakistan. So far in 2019, majority of the new cases were reported in KP. It may be due to polio immunization program has been accused in the region. Moreover, Pakistan and Afghanistan share a long border which is located in this region. A repeatedly substantial population migration occurs between the both countries and significant cross-border activity keep on spreading the virus. In Pakistan, an estimated 1,400,000 Afghan people (refugees) are unregistered while the number of registered refugees are 1,543,55615.

The authorities prefer to facilitate the registered refugees first, sometime leaving some unregistered people un-vaccinated. Insecurity of polio workers is also associated with increased incidence of polio. Discrepancy theories about vaccines and literacy rate are correlated. Due to low literacy rate in KP, the awareness about polio is low. To reach at zero polio case, some basic strategies need to be adopted particularly in the high-risk zones of the country. By tackling the misconception of parents against vaccinations, retaining public trust, improving coordination between government and non-government organizations and health institutes, community engagement and mobilization, ensuring normal vaccine supply to the rural and remote areas, strengthening the routine immunization infrastructure, adequate financing and polio workers safety may lead to eradicate the polio from the country.


In Pakistan during the past and the recent gunning down of polio workers and parental refusal has seen which resulted setback and failure of polio eradication. This might be one of the reasons of current polio outbreak in the country. Both the countries, Afghanistan and Pakistan must work together to stop the polio for good, with an effective strategies and an emphasis on high-quality immunization activities and disease surveillance to fulfill the remaining immunity missing gaps.


AJK: Azad Jammu and Kashmir

cVDPV: Circulating Vaccine-derived Poliovirus

FATA: Federally Administered Tribal Areas

GB: Gilgit-Baltistan

IDP: Internally Displaced People

IPV: Inactivated Polio Vaccine

KP: Khyber Pakhtunkhwa

WHO: World Health Organization

WPV1: Wild Poliovirus Type 1


The authors declared no conflicts of interest.


TA: Designed the study, collected the data and wrote the manuscript. H: Helped in writing. MK, THM, MB, FN and JH: Edited and reviewed the manuscript. TA: Supervised the study.


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