Abstract

Thrombotic thrombocytopenic purpura (TTP), a rare and potentially life-threatening blood disorder, poses unique challenges during pregnancy. It is characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and microvascular thrombosis. Pregnancy induces significant changes in hemodynamics and coagulation factors, complicating the already complex pathophysiology and presentation of TTP. TTP during pregnancy may be clinically challenging due to overlapping features with other thrombotic microangiopathies. Here, we report a 34-year-old woman at 12 weeks of gestation who presented with sudden onset of altered sensorium and fever. Initial investigations revealed anemia, thrombocytopenia, and numerous schistocytes in the peripheral blood smear. She was diagnosed with TTP based on clinical symptoms and laboratory findings. Ensuring correct diagnosis and management is critical because of the impact on fetal and maternal outcomes.