<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD v1.1d1 20130915//EN" "JATS-archivearticle1.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="letter" dtd-version="1.1d1">
  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>Biomedical Research and Therapy</journal-title>
      </journal-title-group>
      <issn pub-type="epub" publication-format="electronic">2198-4093</issn>
      <publisher>
        <publisher-name>BioMedPress</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.15419/bmrat.v4i08.204</article-id>
      <article-categories>
        <subj-group subj-group-type="display-channel">
          <subject>Letter</subject>
        </subj-group>
        <subj-group subj-group-type="heading">
          <subject>Biomedical Research and Therapy</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Global strategy and targets to reach end the global tuberculosis epidemic</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Veisani</surname>
            <given-names>Yousef</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Delpisheh</surname>
            <given-names>Ali</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author" corresp="yes">
          <name>
            <surname>Khazaei</surname>
            <given-names>Salman</given-names>
          </name>
          <xref ref-type="aff" rid="aff3"/>
          <xref ref-type="corresp" rid="cor1">*</xref>
        </contrib>
        <aff id="aff1">
          <institution>Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran</institution>
        </aff>
        <aff id="aff2">
          <institution>Department of Clinical Epidemiology, Ilam University of Medical Sciences, Ilam, Iran</institution>
        </aff>
        <aff id="aff3">
          <institution>Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran</institution>
        </aff>
      </contrib-group>
      <author-notes>
        <corresp id="cor1"><label>*</label>For correspondence: <email>salman.khazaei61@gmail.com</email></corresp>
        <fn fn-type="con" id="equal-contrib">
          <label>*</label>
          <p>These authors contributed equally to this work</p>
        </fn>
      </author-notes>
      <pub-date date-type="pub" publication-format="electronic">
        <day>15</day>
        <month>08</month>
        <year>2017</year>
      </pub-date>
      <volume>4</volume>
      <issue>8</issue>
      <fpage>1</fpage>
      <lpage>4</lpage>
      <history>
        <date date-type="received">
          <day>04</day>
          <month>08</month>
          <year>2017</year>
        </date>
        <date date-type="accepted">
          <day>13</day>
          <month>08</month>
          <year>2017</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>Copyright: &#169; The Author(s) 2017</copyright-statement>
        <copyright-year>2017</copyright-year>
        <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/CC-BY/4.0">
          <license-p>This article is published with open access by BioMedPress (BMP), Laboratory of Stem Cell Research and Application, Vietnam National University, Ho Chi Minh city, Vietnam This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.</license-p>
        </license>
      </permissions>
      <self-uri content-type="pdf" xlink:href="http://www.bmrat.org/index.php/BMRAT/article/view/204/537"/>
      <abstract>
        <p>Tuberculosis (TB) has the second highest death rate in the world among infectious diseases after HIV/AIDS (Wei et al., 2016). TB epidemic is more important than it was supposed to be (Raviglione and Sulis, 2016). In 2015, 10.4 million new cases were occurred worldwide, among these, 5.9 million (56%) were male, 3.5 million (34%) were female, and 1.0 million (10%) of them was the child. It should be noted that 1.2 million (11%) of all new TB cases were occurred in people that living with HIV (PWLH). Although tuberculosis deaths are declined by about 22% between 2000 to 2015, still is remained among top 10 causes of death in 2015 (Uplekar et al., 2015; WHO, 2016).</p>
      </abstract>
      <kwd-group>
</kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="s1">
      <title>Letter</title>
      <p>Tuberculosis (TB) has the second highest death rate in the world among infectious diseases after HIV/AIDS (Wei et al., 2016). TB epidemic is more important than it was supposed to be <xref ref-type="bibr" rid="ref4">Raviglione and Sulis, 2016</xref>. In 2015, 10.4 million new cases were occurred worldwide, among these, 5.9 million (56%) were male, 3.5 million (34%) were female, and 1.0 million (10%) of them was the child.</p>
      <p>It should be noted that 1.2 million (11%) of all new TB cases were occurred in people that living with HIV (PWLH). Although tuberculosis deaths are declined by about 22% between 2000 to 2015, still is remained among top 10 causes of death in 2015 <xref ref-type="bibr" rid="ref6">Uplekar et al., 2015</xref><xref ref-type="bibr" rid="ref8">WHO, 2016</xref>.</p>
      <p>The three indicators for the End TB Strategy was conducted by the United Nations in 2015; percent of the reduction in some TB deaths, percent of the reduction in TB incidence rate, and percent of TB-affected families facing catastrophic costs due to TB. Indicators were targeted for the years 2030 and 2035, by milestones in 2020 and 2025, respectively <xref ref-type="bibr" rid="ref3">L&#246;nnroth and Raviglione, 2016</xref><xref ref-type="bibr" rid="ref6">Uplekar et al., 2015</xref><xref ref-type="bibr" rid="ref8">WHO, 2016</xref> (<xref ref-type="fig" rid="tab1"> Table 1 </xref>).</p>
      <fig id="tab1">
        <label>Table 1</label>
        <caption>
          <p>The Sustainable Development Goals (SDGs) for 2030 and End TB 2035 targets</p>
        </caption>
        <graphic xlink:href="bmrat.v4i08.204/tab1.png"/>
      </fig>
      <p>To achieve these targets, the annual TB incidence rates should be reduced to 10% per year by 2025 (from 2% per year in 2015). In second, the case-fatality ratio must be decline to 6.5% by 2025 (from 15% in 2015). As projected to maintain progress after millstone time and achieve the Sustainable Development Goals (SDGs) for 2030 and End TB 2035 targets new tools should be available in 2025 that compromise a new vaccine, conduct a new diagnostic approach, and more effective treatment  for TB disease <xref ref-type="bibr" rid="ref5">Taghizade Moghaddam et al., 2016</xref><xref ref-type="bibr" rid="ref8">WHO, 2016</xref> (<xref ref-type="fig" rid="fig1"> Figure 1 </xref>).</p>
      <fig id="fig1">
        <label>Figure 1</label>
        <caption>
          <p>A predicted trend in global TB incidence rates to reach the 2035</p>
        </caption>
        <graphic xlink:href="bmrat.v4i08.204/fig1.png"/>
      </fig>
      <p>It is apparently detectable that failure in achieving to SDGs for 2030 and End TB 2035 targets will take severe concerns in both individual and global public health outcomes <xref ref-type="bibr" rid="ref2">Dirlikov et al., 2015</xref><xref ref-type="bibr" rid="ref3">L&#246;nnroth and Raviglione, 2016</xref>. WHO recommended implications for TB preventions such as encouraging the private sector to participate in TB care especially in low-income countries, documenting and evaluating social protection and economic support for TB patients in low-and middle income countries to assess of impact and sustainability, conducts of national surveys to assess of improve services to TB patient, beside these ending TB in world links to ending risk factors of poverty, such as non-communicable disease prevention, food security, and housing <xref ref-type="bibr" rid="ref3">L&#246;nnroth and Raviglione, 2016</xref>.</p>
      <p>In finally above prevention strategies must be accompanied by priorities action plan for global progress towards TB and achieve to SDGs for 2030 and End TB 2035. Priorities action plan are following; identify undiagnosed cases (3 million not in TB care), MDR-TB crisis plan to deal with, appropriate and prompt treatment of TB/HIV cases, increase financing support at national level, and support innovation in the field of TB <xref ref-type="bibr" rid="ref1">Cousins, 2016</xref><xref ref-type="bibr" rid="ref8">WHO, 2016</xref>.</p>
    </sec>
    <sec id="s2">
      <title>Abbreviation</title>
      <p>Tuberculosis (TB)</p>
      <p>Sustainable Development Goals (SDGs)</p>
      <p>World Health Organization (WHO)</p>
    </sec>
    <sec id="s3">
      <title>Author contribution</title>
      <p>All authors contributed in manuscript preparation. Veisani,Y and Khazaei,S obtained data and analyzed it. Delpisheh, A interpreted of data analysis. All authors drafted the first version and approve the final draft.</p>
    </sec>
  </body>
  <back>
    <ref-list>
      <title>References</title>
      <ref id="ref1">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>S.</surname>
              <given-names>Cousins</given-names>
            </name>
          </person-group>
          <article-title>Funding shortfalls put target to end TB epidemic by 2035 at risk</article-title>
          <source>BMJ</source>
          <year>2016</year>
          <volume>355</volume>
        </element-citation>
      </ref>
      <ref id="ref2">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>E.</surname>
              <given-names>Dirlikov</given-names>
            </name>
            <name>
              <surname>M.</surname>
              <given-names>Raviglione</given-names>
            </name>
            <name>
              <surname>F.</surname>
              <given-names>Scano</given-names>
            </name>
          </person-group>
          <article-title>Global tuberculosis control: Toward the 2015 targets and beyond</article-title>
          <source>Annals of Internal Medicine</source>
          <year>2015</year>
          <volume>163</volume>
          <fpage>52</fpage>
          <lpage>58</lpage>
        </element-citation>
      </ref>
      <ref id="ref3">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>K.</surname>
              <given-names>L&#246;nnroth</given-names>
            </name>
            <name>
              <surname>M.</surname>
              <given-names>Raviglione</given-names>
            </name>
          </person-group>
          <article-title>The WHO's new End TB Strategy in the post-2015 era of the Sustainable Development Goals</article-title>
          <source>Transactions of the Royal Society of Tropical Medicine and Hygiene</source>
          <year>2016</year>
          <volume>110</volume>
          <fpage>148</fpage>
          <lpage>150</lpage>
        </element-citation>
      </ref>
      <ref id="ref4">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>M.</surname>
              <given-names>Raviglione</given-names>
            </name>
            <name>
              <surname>G.</surname>
              <given-names>Sulis</given-names>
            </name>
          </person-group>
          <article-title>Tuberculosis 2015: Burden, Challenges and Strategy for Control and Elimination</article-title>
          <source>Infectious Disease Reports</source>
          <year>2016</year>
          <volume>8</volume>
          <fpage>6570</fpage>
        </element-citation>
      </ref>
      <ref id="ref5">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>H.</surname>
              <given-names>Taghizade Moghaddam</given-names>
            </name>
            <name>
              <surname>Z.</surname>
              <given-names>Emami Moghadam</given-names>
            </name>
            <name>
              <surname>G.</surname>
              <given-names>Khademi</given-names>
            </name>
            <name>
              <surname>A.</surname>
              <given-names>Bahreini</given-names>
            </name>
            <name>
              <surname>M.</surname>
              <given-names>Saeidi</given-names>
            </name>
          </person-group>
          <article-title>Tuberculosis: Past, Present and Future</article-title>
          <source>International Journal of Pediatrics</source>
          <year>2016</year>
          <volume>4</volume>
          <fpage>1243</fpage>
          <lpage>1254</lpage>
        </element-citation>
      </ref>
      <ref id="ref6">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>M.</surname>
              <given-names>Uplekar</given-names>
            </name>
            <name>
              <surname>D.</surname>
              <given-names>Weil</given-names>
            </name>
            <name>
              <surname>K.</surname>
              <given-names>Lonnroth</given-names>
            </name>
            <name>
              <surname>E.</surname>
              <given-names>Jaramillo</given-names>
            </name>
            <name>
              <surname>C.</surname>
              <given-names>Lienhardt</given-names>
            </name>
            <name>
              <surname>H.M.</surname>
              <given-names>Dias</given-names>
            </name>
            <name>
              <surname>D.</surname>
              <given-names>Falzon</given-names>
            </name>
            <name>
              <surname>K.</surname>
              <given-names>Floyd</given-names>
            </name>
            <name>
              <surname>G.</surname>
              <given-names>Gargioni</given-names>
            </name>
            <name>
              <surname>H.</surname>
              <given-names>Getahun</given-names>
            </name>
          </person-group>
          <article-title>WHO's new End TB Strategy</article-title>
          <source>The Lancet</source>
          <year>2015</year>
          <volume>385</volume>
          <fpage>1799</fpage>
          <lpage>1801</lpage>
        </element-citation>
      </ref>
      <ref id="ref7">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>W.</surname>
              <given-names>Wei</given-names>
            </name>
            <name>
              <surname>Z.</surname>
              <given-names>Wei-Sheng</given-names>
            </name>
            <name>
              <surname>A.</surname>
              <given-names>Ahan</given-names>
            </name>
            <name>
              <surname>Y.</surname>
              <given-names>Ci</given-names>
            </name>
            <name>
              <surname>Z.</surname>
              <given-names>Wei-Wen</given-names>
            </name>
            <name>
              <surname>C.</surname>
              <given-names>Ming-Qin</given-names>
            </name>
          </person-group>
          <article-title>The Characteristics of TB Epidemic and TB/HIV Co-Infection Epidemic: A 2007-2013 Retrospective Study in Urumqi, Xinjiang Province, China</article-title>
          <source>PLOS ONE</source>
          <year>2016</year>
          <volume>11</volume>
          <fpage>e0164947</fpage>
        </element-citation>
      </ref>
      <ref id="ref8">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name name-style="given-only">
              <given-names>WHO</given-names>
            </name>
          </person-group>
          <article-title>Global Tuberculosis Report</article-title>
          <year>2016</year>
        </element-citation>
      </ref>
    </ref-list>
  </back>
</article>