TY - JOUR AU - Nguyen Hung AU - Trinh Nam AU - Nguyen Huu AU - Nguyen Thanh AU - Tran Minh AU - Nguyen Nga AU - Nguyen Nam AU - Tran Chuong AU - Doan Khuy AU - Dao Luan AU - Hoang Mai PY - 2023/02/28 Y2 - 2024/03/29 TI - Case series of rare primary cardiac sarcomas: A challenging histopathological diagnosis JF - Biomedical Research and Therapy JA - BMRAT VL - 10 IS - 2 SE - Case report DO - 10.15419/bmrat.v10i2.791 UR - http://bmrat.org/index.php/BMRAT/article/view/791 AB - Primary cardiac sarcomas are rare and histologically diverse, with single tumors able to demonstrate histological heterogeneity. Consequently, they are often misdiagnosed as other common cardiac tumors, such as cardiac myxoma or other metastatic malignancies. Incorrect diagnoses can result in incomplete surgeries, inadequate treatment regimens, and early recurrence. In our experience, based on the diverse histological and cytological characteristics of these tumors, immunostaining panels should be used early on to differentiate the exact tumor type. SMA, CD31, myogenin, ERG, and SOX10 panels are used to identify spindle-shaped or polymorphic cell patterns, while CK, LCA, S100, and desmin panels are used for round and monomorphic cell patterns. Using these panels can help identify the histological type of primary cardiac sarcomas, which is normally a challenge for pathologists. ER -